The Facts and Nothing But the Facts

The Critical Facts

There is no prevention. There is no cure. Breast cancer knows no boundaries of race or class.

Number of Breast Cancer Cases in the United States

Breast cancer is the most common cancer among women, excluding cancers of the skin. More than 2 million women are living with the disease.1 In 2007, breast cancer will account for nearly one out of every four cancer diagnoses in women.2

An estimated 178,480 women will be diagnosed with invasive breast cancer in 2007. This number does not include cases of carcinoma in situ. An estimated 62,030 new cases of breast carcinoma in situ will be diagnosed in 2007. Of these, 85% will be ductal carcinoma in situ (DCIS).3

If every woman lived to age 85, one out of eight women in the United States would develop breast cancer by that time—a “lifetime” risk that was one out of 14 in 1980.4 A new breast cancer case is diagnosed every 2.2 minutes.5

Men develop breast cancer, too, although they account for approximately 1% of cases. In 2007 an estimated 2,030 cases will be diagnosed among men.6

Breast Cancer Risk

Breast cancer knows no racial boundaries. Overall, white women are most likely to be diagnosed with breast cancer, while black women are more likely to die from the disease.7 For women under age 35, black women have a higher incidence than white women.8

Risk increases with age. The chance of a woman under the age of 39 developing breast cancer is 1 in 210. From ages 40-59 it is 1 in 25, from ages 60-69 it is 1 in 27 and from ages 70 and older it is 1 in 15.9

Every woman is at risk for breast cancer. More than 50% of breast cancers occur in women who have no identifiable risk factors other than age.10 Only 5 to 10% of breast cancers are linked to inherited mutations in BRCA1 and BRCA 2 genes.11

Mortality Rates

Cancer accounts for 1 in every 4 deaths in the U.S. and kills more people than any other cause, except for heart disease. 12

In the U.S., breast cancer is the second leading cause of cancer death among women as a whole (lung cancer is the first).13 In 2007, an estimated 40,910 deaths will be attributed to breast cancer (40,460 women, 450 men).14 A woman dies from breast cancer every 13 minutes.15

Black women with breast cancer are dying younger than other women with breast cancer. The median age at death for white breast cancer patients is 70 years; for black breast cancer patients it is 61 years.16

Survival Rates

89% of women diagnosed with breast cancer 5 years ago are still alive. Of those diagnosed 10 years ago, 80% are still alive; of those diagnosed 20 years ago, 63% are still alive.17

According to the most recent cancer statistics review, black women are less likely than white women to survive 5 years after a breast cancer diagnosis: 77% versus 90% respectively.18

Five-year survival rates also vary according to age of diagnosis: 83% for women under age 45, 87% for women aged 45-54, and just over 88% for women age 55 and older.19

Mammography

Mammograms do not prevent breast cancer. They detect tumors, but can miss more than a 1/4 of all breast cancers.20 Additionally, mammograms can cause “false positive” results when a mammogram finds something in the breast that, on biopsy, proves not to be cancer. As many as 3/4 of all post-mammogram biopsy results turn out to be benign lesions.21

Mammography may not be effective in detecting breast cancer for women who are pre-menopausal. Although 50 is often used as the estimated age for women to begin menopause, it is not an accurate indicator of menopausal status. Because the breast tissue of pre-menopausal women tends to be denser than that of post-menopausal women, mammograms of younger women may be more difficult to read.22

Income

A lack of medical insurance and poor access to screening and treatment decrease survival. Low-income breast cancer patients have 5-year relative survival rates that are 9% lower than higher-income patients. Low-income African American women are three times more likely than higher-income African American women to be diagnosed with advanced disease.23

Insurance

In 2004, only 40% of uninsured women reported having had a mammogram in the past two years, compared with 74% of insured women.24

Uninsured women and women on Medicaid are more likely to be diagnosed at a later stage of breast cancer and are 30-50% more likely to die than women with private health insurance.25

Approximately 48 million people in the United States had no health insurance coverage in 2005.26

The Environment

In 2004, U.S. industries reported the release of 4.24 billion pounds of toxic chemicals.27 In general, this represents only a portion of all toxic chemical releases nationwide because not all facilities, and not all toxic chemicals, are required to be reported. Additionally, TRI data reflect disposal or other releases and other waste management of chemicals, and not exposures of the public to those chemicals.28

An estimated 80,000 chemicals are in commercial use today.29 More than 90% have never been tested for human health effects.30

Environmental estrogens, chemicals foreign to the body that mimic estrogen (which controls the growth of breast cells) are found in what we eat, drink, breathe, and in compounds we use at work, home, and in the garden. So far, 100 chemicals have been found to be estrogenic.31

Today, 216 commonly used chemicals are known to induce breast tumors in laboratory animals.32

1 Ries LAG, et al. SEER Cancer Statistics Review, 1975-2003. Retrieved June 2006 from the National Cancer Institute website http://seer.cancer.gov/csr/1975_2003/
Based on November 2005 SEER data submission, posted to the SEER web site 2006. On January 1, 2003, there were approximately 2,356,795 women alive who had a history of breast cancer.

2 American Cancer Society. Cancer Facts & Figures 2007.
Breast cancer represents approximately 26% of total cancer cases in women.

3 American Cancer Society. Cancer Facts & Figures 2007.

4 American Cancer Society. Breast Cancer Facts & Figures 2005-2006.
A woman’s lifetime risk is 12.67%, or 1 in 8.

5 The following calculations were used for this statistic and include cases of carcinoma in situ:
365 days x 24 hours/day x 60minutes/hour = 525,600 minutes/year
525,600 minutes/year / 240,510 cases/year = 2.2 minutes/case

6 American Cancer Society. Cancer Facts & Figures 2007.

7 National Cancer Institute, Surveillance Epidemiology and End Results program (NCI SEER). Cancer Stat Fact Sheets. Retrieved June 2006 from the National Cancer Institute Website http://seer.cancer.gov/statfacts
SEER statistics are based on data collected at cancer registries in various areas of the country and are always a few years behind. These rates are based on cases diagnosed in 2000-2003. Incidence for white women is 134.0 per 100,000 vs. 118.0 for black women; mortality is 25.3 per 100,000 for white women versus 34.3 per 100,000 for black women.

8 American Cancer Society, Breast Cancer Facts & Figures 2005-2006.

9 American Cancer Society, Cancer Facts & Figures 2007.

10 U.S. General Accounting Office. Breast Cancer, 1971-1991: Prevention, Treatment and Research. GAO/PEMD-92-12; 1991.
States that all the known risk factors account for only 20-30% of all breast cancer cases.

Silent Spring Institute. Frequently Asked Questions: Risk Factors. Retrieved July 2006 at http://www.silentspring.org/newweb/about/faqs_4risk.html.
States that less than half of breast cancer risk is explained by the known risk factors.

11 American Cancer Society, Cancer Facts & Figures 2007.

12 American Cancer Society, Cancer Facts & Figures 2007.

13 American Cancer Society, Cancer Facts & Figures 2007.

14 American Cancer Society, Cancer Facts & Figures 2007.

15 The following calculations were used for this statistic:
365 days x 24 hours/day x 60minutes/hour = 525,600 minutes/year
525,600 minutes/year / 40,910 deaths/year = 12.8 (rounded to 13) minutes/deaths

16 NCI SEER CSR 1975-2003; Breast Cancer, Table I-13. Retrieved June 2006 from the National Cancer Institute Website http://seer.cancer.gov/csr/1975_2003/sections.html

17 American Cancer Society, Breast Cancer Facts & Figures 2005-2006.

18 Ries LAG, et al. SEER Cancer Statistics Review, 1975-2003. Retrieved 2006 from the National Cancer Institute Website http://seer.cancer.gov/csr/1975_2003/
Based on November 2005 SEER data submission, posted to the SEER web site, 2006.

19 Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 9 Regs Public-Use, Nov 2004 Sub (1973-2002), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005, based on the November 2004 submission.

20 24-27% cited in Yankaskas B et al., “Association of recall rates with sensitivity and positive predictive values of screening mammography,” American Journal of Roentgen Ray Society, 2001 Sep; 177[3]:543-9.
28% cited in Poplack S et al., “Mammography in 53,803 Women from the New Hampshire Mammography Network,” Radiology, 2000 Dec; 217:832-840.

21 Institute of Medicine/National Resource Council, Mammography and Beyond, National Academy Press: Washington DC. 2001; pg. 39.

22 Love, Susan, Dr. Susan Love’s Breast Book, 3rd ed. , Perseus Publishing: MA. 2000; p. 125.

23 National Cancer Institute, Breast Cancer Research and Programs: An Overview, Bethesda, MD, 1995; as cited in Breast Cancer Facts & Figures 1999-2000

24 Kaiser Family Foundation, Women’s Health Policy Program. Women and healthcare: a national profile. Findings from the Kaiser Women’s Health Survey, July 2005. Retrieved June 2006 from the Kaiser Family Foundation Website
http://www.kff.org/womenshealth/7336.cfm

25 Institute of Medicine (2002). Care without coverage: too little, too late. Retrieved June 2006 from the National Academies Press Washington, DC Website http://darwin.nap.edu/books/0309083435/html/54.html

26 Families USA. Paying a Premium: The Added Cost of Care for the Uninsured. Retrieved June 2005 from http://familiesusa.org/resources/publications/reports/paying-a-premium-findings.html

27 U.S. Environmental Protection Agency. Toxics release inventory public data release brochure. Retrieved June 2006 from the U.S. Environmental Protection Agency Website http://www.epa.gov/tri/tridata/tri00/press/execsummary_final.pdf
This number is lower in 2000 due in part to an EPA reporting exemption for coal extraction activities. U.S. Environmental Protection Agency. EPCRA Section 313 Questions and Answers. Retrieved July 2006 at www.epa.gov/tri/guide_docs/1998/1998qa.pdf

28 U.S.Environmental Protection Agency. Retrieved July 2006 at http://www.epa.gov/triexplorer/introduction.htm

29 U.S. Environmental Protection Agency. TSCA Inventory Update Rule Ammendments 2003. Retrieved March 2007 at http://www.epa.gov/EPA-TOX/2003/January/Day-07/t32909.htm.

30 Bennet M, Davis BJ. The identification of mammary carcinogens in rodent bioassays, Environmental and Molecular Mutagenesis: 2002.

31 Silent Spring Institute. Retrieved July 2006 at www.silentspring.org/newweb/about/faqs_4risk.html

32 Silent Spring Institute, "Chemicals causing mammary gland tumors in animals signal new directions for epidemioloy, chemicals testing, and risk assessment for breast cancer prevention," Cancer, May, 14, 2007

(Updated May 2007)